4-氨基-N-[2-(二甲基氨基)乙基]苯甲酰胺合成路线 （共 3 条）
反应条件
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine in N,N-dimethyl-formamide T=20°C;
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; MENICHINCHERI, Maria; ANGIOLINI, Mauro; BERTRAND, Jay Aaron; CARUSO, Michele; POLUCCI, Paolo; QUARTIERI, Francesca; SALOM, Barbara; SALSA, Matteo; ZUCCOTTO, Fabio
Patent: WO2014/72220 A1, 2014 ;
Location in patent: Page/Page column 49 ;
反应条件
1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C 2: hydrogen / palladium on activated charcoal / methanol View Scheme
参考文献
AURIGENE DISCOVERY TECHNOLOGIES LIMITED; SENGUPTA, Saumitra; RAJAGOPALAN, Srinivasan; BELAVAGI, Ningaraddi; RAMACHANDRA, Muralidhara
Patent: WO2012/59932 A1, 2012 ;
WO 2012/059932 A1
反应条件
1: triethylamine / dichloromethane / 48 h / 20 °C / |Inert atmosphere 2: hydrogen; 10 Pd/C / methanol / 20 °C / 15001.5 Torr View Scheme
参考文献
Lawrence, Harshani R.; Martin, Mathew P.; Luo, Yunting; Pireddu, Roberta; Yang, Hua; Gevariya, Harsukh; Ozcan, Sevil; Zhu, Jin-Yi; Kendig, Robert; Rodriguez, Mercedes; Elias, Roy; Cheng, Jin Q.; Sebti, Said M.; Schonbrunn, Ernst; Lawrence, Nicholas J.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 17 p. 7392 - 7416
