2-氯-4-甲基-5-嘧啶羧酸合成路线 （共 4 条）
反应条件
sodium hydroxide T=20°C; Hydrolysis; 3 h;
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
1: 88 percent / NaOEt / ethanol / 72 h / 20 °C 2: 27 percent / POCl3 / 1 h / Heating 3: 78 percent / aq. NaOH / 3 h / 20 °C View Scheme
参考文献
Journal of medicinal chemistry, , vol. 43, # 21 p. 3995 - 4004
反应条件
in dichloromethane; N,N-dimethyl-formamide
参考文献
Signal Pharmaceuticals, Inc.
Patent: US5811428 A1, 1998 ;
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; Chlorination; 4 h;
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
