4-甲基-2-羟基嘧啶-5-羧酸合成路线 （共 6 条）
参考文献
Signal Pharmaceuticals, Inc.
Patent: US5811428 A1, 1998 ;
反应条件
1: With n-butyllithium in hexane; toluene T=-75°C; 2: With hydrogenchloride in water
参考文献
Schlosser, Manfred; Lefebvre, Olivier; Ondi, Levente
European Journal of Organic Chemistry, 2006 , # 6 p. 1593 - 1598
反应条件
sodium hydroxide in tetrahydrofuran Hydrolysis;
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1: 45 percent / NaOEt / ethanol / Heating 2: POCl3 / 1 h / Heating 3: 1 N aq. NaOH / tetrahydrofuran View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1: POCl3 / 1 h / Heating 2: 1 N aq. NaOH / tetrahydrofuran View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane Chlorination;
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
