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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
188860-26-6
合成路线
(共 7 条)
1248696-03-8
+
54998-08-2
4-(4-甲基哌嗪基)-1,2-苯二胺
→
反应条件
188860-26-6
反应条件
Na2S2O5 in ethanol; water 6 h; Reflux;
参考文献
Singh, Manish; Tandon, Vibha
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669
109-01-3
N-甲基哌嗪
→
反应条件
188860-26-6
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 110 °C 2: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 724.03 - 2172.08 Torr 3: Na2S2O5 / ethanol; water / 6 h / Reflux View Scheme
参考文献
Singh, Manish; Tandon, Vibha
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669
1248695-97-7
→
反应条件
188860-26-6
反应条件
1: nickel-aluminum alloy; formic acid / water / 5 h / 95 °C / Inert atmosphere 2: Na2S2O5 / ethanol; water / 6 h / Reflux View Scheme
参考文献
Singh, Manish; Tandon, Vibha
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669
1635-61-6
2-硝基-5-氯苯胺
→
反应条件
188860-26-6
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 110 °C 2: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 724.03 - 2172.08 Torr 3: Na2S2O5 / ethanol; water / 6 h / Reflux View Scheme
参考文献
Singh, Manish; Tandon, Vibha
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669
17626-40-3
3,4-二氨基苯甲腈
→
反应条件
188860-26-6
反应条件
1: Na2S2O5 / ethanol; water / 5 h / Reflux 2: nickel-aluminum alloy; formic acid / water / 5 h / 95 °C / Inert atmosphere 3: Na2S2O5 / ethanol; water / 6 h / Reflux View Scheme
参考文献
Singh, Manish; Tandon, Vibha
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669
6393-40-4
4-氨基-3-硝基苯甲腈
→
反应条件
188860-26-6
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol / 0.5 h / 20 °C / 1137.76 - 2172.08 Torr 2: Na2S2O5 / ethanol; water / 5 h / Reflux 3: nickel-aluminum alloy; formic acid / water / 5 h / 95 °C / Inert atmosphere 4: Na2S2O5 / ethanol; water / 6 h / Reflux View Scheme
参考文献
Singh, Manish; Tandon, Vibha
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669
23491-48-7
5-(4-甲基哌嗪)-2-硝基苯胺
→
反应条件
188860-26-6
反应条件
1: palladium 10 on activated carbon; hydrogen / ethanol / 2 h / 20 °C / 724.03 - 2172.08 Torr 2: Na2S2O5 / ethanol; water / 6 h / Reflux View Scheme
参考文献
Singh, Manish; Tandon, Vibha
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 659 - 669