4-(4-溴苯基)-1,2,36-四氢-1-苯甲基-吡啶合成路线 （共 8 条）
反应条件
1: p-bromophenyl bromide With n-butyllithium in tetrahydrofuran; hexane T=-60 - -50°C; 0.333333 h; 2: 1-(phenylmethyl)-1,2,3,6-tetrahydropyridine in tetrahydrofuran; hexane T=20°C;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2004/192729 A1, 2004 ;
Location in patent: Page 33 ;
反应条件
toluene-4-sulfonic acid in toluene Heating;
参考文献
Wenzel, Barbara; Sorger, Dietlind; Heinitz, Katrin; Scheunemann, Matthias; Schliebs, Reinhard; Steinbach, Joerg; Sabri, Osama
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 12 p. 1197 - 1205
反应条件
tetrabutyl ammonium fluoride; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in tetrahydrofuran T=20°C;
参考文献
Morrill, Christie; Mani, Neelakandha S.
Organic Letters, 2007 , vol. 9, # 8 p. 1505 - 1508
反应条件
1: 83 percent / tetrahydrofuran / 4 °C 2: 55 percent / p-toluenesulfonic acid monohydrate / toluene / Heating View Scheme
参考文献
Vieira, Eric; Binggeli, Alfred; Breu, Volker; Bur, Daniel; Fischli, Walter; Gueller, Rolf; Hirth, Georges; Maerki, Hans Peter; Mueller, Marcel; Oefner, Christian; Scalone, Michelangelo; Stadler, Heinz; Wilhelm, Maurice; Wostl, Wolfgang
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 10 p. 1397 - 1402
反应条件
1: n-BuLi, THF / -70 °C 2: p-TsOH*H2O / toluene / Heating View Scheme
参考文献
Vieira, Eric; Binggeli, Alfred; Breu, Volker; Bur, Daniel; Fischli, Walter; Gueller, Rolf; Hirth, Georges; Maerki, Hans Peter; Mueller, Marcel; Oefner, Christian; Scalone, Michelangelo; Stadler, Heinz; Wilhelm, Maurice; Wostl, Wolfgang
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 10 p. 1397 - 1402
反应条件
1: 83 percent / tetrahydrofuran / 4 °C 2: 55 percent / p-toluenesulfonic acid monohydrate / toluene / Heating View Scheme
参考文献
Wenzel, Barbara; Sorger, Dietlind; Heinitz, Katrin; Scheunemann, Matthias; Schliebs, Reinhard; Steinbach, Joerg; Sabri, Osama
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 12 p. 1197 - 1205
反应条件
1: 100 percent / K2CO3 / dimethylformamide / 12 h / 20 °C 2: 34 percent / p-TsOH*H2O / toluene / 1 h / Heating View Scheme
参考文献
Kaneko, Toshihiko; Clark, Richard S. J.; Ohi, Norihito; Ozaki, Fumihiro; Kawahara, Tetsuya; Kamada, Atsushi; Okano, Kazuo; Yokohama, Hiromitsu; Ohkuro, Masayoshi; Muramoto, Kenzo; Takenaka, Osamu; Kobayashi, Seiichi
Chemical and Pharmaceutical Bulletin, 2004 , vol. 52, # 6 p. 675 - 687
反应条件
hydrogen; acetic acid; palladium on activated charcoal in ethanol
参考文献
Wenzel, Barbara; Sorger, Dietlind; Heinitz, Katrin; Scheunemann, Matthias; Schliebs, Reinhard; Steinbach, Joerg; Sabri, Osama
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 12 p. 1197 - 1205
