1: ethyl 2-[bis(2-isopropylphenoxy)phosphoryl]acetate With N-benzyl-trimethylammonium hydroxide in tetrahydrofuran; methanol T=-78°C; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; 2: pyridine-2-carbaldehyde in tetrahydrofuran; methanol T=-78°C; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; Overall yield = 78 percent; diastereoselective reaction;

1: ethyl 2-[bis(2-isopropylphenoxy)phosphoryl]acetate With N-benzyl-trimethylammonium hydroxide in tetrahydrofuran; methanol T=-78°C; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; 2: 2,3-dihydrobenzo[b]furan-5-carboxaldehyde in tetrahydrofuran; methanol T=-78°C; Horner-Wadsworth-Emmons Olefination; Inert atmosphere; Overall yield = 78 percent; diastereoselective reaction;