3,6-二氢-2H-吡喃-4-三氟甲烷磺酸盐合成路线 （共 11 条）
反应条件
1: tetrahydro-pyran-4-one With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 0.5 h; Inert atmosphere; 2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Jana, Navendu; Nguyen, Quyen; Driver, Tom G.
Journal of Organic Chemistry, 2014 , vol. 79, # 6 p. 2781 - 2791
反应条件
1: tetrahydro-pyran-4-one With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78 - 0°C; 2 h; Inert atmosphere; 2: N-(5-chloropyridin-2-yl)-1,1,1-trifluoro-N-[(trifluoromethyl)sulfonyl]methanesulfonamide in tetrahydrofuran; hexane T=0°C; 3.25 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; UNIVERSITE DE MONTREAL; PRIESTLEY, Eldon Scott; POSY, Shoshana L.; TREMBLAY, Francois Tremblay; MARTEL, Alain; MARINIER, Anne
Patent: WO2013/163241 A1, 2013 ;
Location in patent: Paragraph 00181 ;
反应条件
1: tetrahydro-pyran-4-one With n-butyllithium; diisopropylamine in tetrahydrofuran; hexane T=-78°C; 2 h; Inert atmosphere; 2: 2-lt;N,N-bis(trifluoromethylsulfonyl)aminogt;-5-chloro-pyridine in tetrahydrofuran; hexane T=0°C; 3 h;
参考文献
Lessard, Stephanie; Peng, Feng; Hall, Dennis G.
Journal of the American Chemical Society, 2009 , vol. 131, # 28 p. 9612 - 9613
反应条件
1: 2,3-Dihydro-4H-pyran-4-one With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78 - -72°C; 1.25 h; Inert atmosphere; 2: N,N-bis(trifluoromethanesulfonyl)aniline in tetrahydrofuran T=-60 - 20°C; Inert atmosphere;
参考文献
PFIZER INC.; BENBOW, John William; LOU, Jihong; PFEFFERKORN, Jeffrey Allen; TU, Meihua Mike
Patent: WO2010/29461 A1, 2010 ;
Location in patent: Page/Page column 40 ;
WO 2010/029461 A1
反应条件
diisopropylamine in tetrahydrofuran; ethyl acetate
参考文献
Zeneca Limited
Patent: US5981528 A1, 1999 ;
参考文献
Pharmacia and Upjohn Company
Patent: US5968962 A1, 1999 ;
反应条件
potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane T=80°C;
参考文献
WO2008/153858 A1, ;
Page/Page column 307 ;
WO 2008/153858 A1
反应条件
N,N'-dimethyl-p-methoxyaniline; (Sc,SFc)-TaniaPhos; palladium diacetate in toluene T=25°C; 16 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 131, # 28 p. 9612 - 9613
反应条件
N,N'-dimethyl-p-methoxyaniline; (Sc,SFc)-TaniaPhos; palladium diacetate in toluene T=80°C; 16 h; Inert atmosphere;
参考文献
Journal of the American Chemical Society, , vol. 131, # 28 p. 9612 - 9613
反应条件
(Sc,SFc)-TaniaPhos; palladium diacetate; N,N-dimethyl-aniline in toluene T=25°C; 16 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 131, # 28 p. 9612 - 9613
