1: 97 percent / methanol / Ambient temperature 2: 81 percent / 15-crown-5-ether / acetonitrile / 1.17 h / Ambient temperature View Scheme

1: 97 percent / methanol / Ambient temperature 2: 92 percent / 15-crown-5-ether, piperidine / acetonitrile / 1.42 h / Ambient temperature View Scheme

<b>Multi-step reaction with 4 steps<br /> </b>1: 90 percent / 30percent NaOH, nBu₄NBr / benzene / 0.08 h / Ambient temperature<br />2: 98 percent / NH₂OH*HCl, Na₂CO₃ / ethanol; H₂O / 0.08 h / 50 &deg;C<br />3: 75 percent / NiCl₂*6H₂O, NaBH₄ / methanol / 0.08 h / Ambient temperature<br />4: 63 percent / CaCO₃ / CH₂Cl₂; H₂O / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1: 90 percent / 30percent NaOH, nBu₄NBr / benzene / 0.08 h / Ambient temperature<br />2: 98 percent / NH₂OH*HCl, Na₂CO₃ / ethanol; H₂O / 0.08 h / 50 &deg;C<br />3: 75 percent / NiCl₂*6H₂O, NaBH₄ / methanol / 0.08 h / Ambient temperature<br />4: 63 percent / CaCO₃ / CH₂Cl₂; H₂O / Ambient temperature<br /> <br /> &nbsp;