6-甲基-2-(4-甲基苯基)咪唑并[1,2-a]吡啶-3-乙酸合成路线 （共 17 条）
反应条件
hydrogenchloride in water T=0°C; 18 h; Heating / reflux;
参考文献
SEPRACOR, INC.; FANG, Kevin; GROVER, Paul; JERUSSI, Tom
Patent: WO2005/44818 A2, 2005 ;
Location in patent: Page/Page column 18 ;
WO 2005/044818 A2
反应条件
water; potassium hydroxide in ethanol T=30°C;
参考文献
Nair, Divya K.; Mobin, Shaikh M.; Namboothiri, Irishi N.N.
Organic Letters, 2012 , vol. 14, # 17 p. 4580 - 4583
反应条件
1: With potassium hydroxide; hydrazine in diethylene glycol T=120 - 180°C; pH=4 - 5; 2: With acetic acid in water; diethylene glycol T=0 - 10°C; pH=6 - 6.5;
参考文献
WO2007/23504 A1, ;
Page/Page column 7-8 ;
反应条件
hydrogenchloride; water
参考文献
George; Rossey; Depoortere; Mompon; Allen
Farmaco, 1991 , vol. 46, # SUPPL. 1 p. 277 - 288
反应条件
potassium hydroxide in ethanol 8 h; Heating;
参考文献
Lange; Karolak-Wojciechowska; Wejroch; Rump
Acta Poloniae Pharmaceutica - Drug Research, 2001 , vol. 58, # 1 p. 43 - 52
反应条件
1: methanol / 0.33 h / 30 °C 2: water; potassium hydroxide / ethanol / 30 °C View Scheme
参考文献
Organic Letters, , vol. 14, # 17 p. 4580 - 4583
反应条件
1: methanol / 0.33 h / 30 °C 2: water; potassium hydroxide / ethanol / 30 °C View Scheme
参考文献
Organic Letters, , vol. 14, # 17 p. 4580 - 4583
反应条件
1: 4-(N,N-dimethlyamino)pyridine / acetonitrile / 30 °C 2: pyridine / dichloromethane / 0.5 h / 0 °C 3: methanol / 0.33 h / 30 °C 4: water; potassium hydroxide / ethanol / 30 °C View Scheme
参考文献
Organic Letters, , vol. 14, # 17 p. 4580 - 4583
反应条件
1.1: 78 percent / acetic acid / H2O / 4 h / 50 - 55 °C 2.1: MeI / ethanol / 24 h / 20 °C 2.2: H2O; ethanol / 4 h / Heating 3.1: 87 percent / aq. KOH / ethanol / 8 h / Heating View Scheme
参考文献
Acta Poloniae Pharmaceutica - Drug Research, , vol. 58, # 1 p. 43 - 52
反应条件
1.1: MeI / ethanol / 24 h / 20 °C 1.2: H2O; ethanol / 4 h / Heating 2.1: 87 percent / aq. KOH / ethanol / 8 h / Heating View Scheme
参考文献
Acta Poloniae Pharmaceutica - Drug Research, , vol. 58, # 1 p. 43 - 52
