6-甲基-2-(4-甲基苯基)咪唑并[1,2-a]吡啶-3-乙酸合成路线 （共 17 条）
反应条件
1: polymer supported sulfonic acid resin / toluene / 120 °C / |Flow reactor 2: tetrafluoroboric acid diethyl ether complex / acetonitrile / 120 °C / |Flow reactor 3: sodium hydroxide; water / ethanol / 90 °C / |Flow reactor View Scheme
参考文献
Chemical Science, , vol. 4, # 2 p. 764 - 769
反应条件
1: tetrafluoroboric acid diethyl ether complex / acetonitrile / 120 °C / |Flow reactor 2: sodium hydroxide; water / ethanol / 90 °C / |Flow reactor View Scheme
参考文献
Chemical Science, , vol. 4, # 2 p. 764 - 769
反应条件
2: 91 percent / H2O, HCl View Scheme
参考文献
Farmaco, , vol. 46, # SUPPL. 1 p. 277 - 288
反应条件
1: 6-methyl-2-(4-methylphenyl)-imidazolt;1,2-agt;pyridine-3-acetic acid With pivaloyl chloride; triethylamine in dichloromethane T=0 - 5°C; 0.5 h; 2: dimethyl amine in dichloromethane; water T=0 - 5°C; 0.5 h;
参考文献
SUVEN LIFE SCIENCES LIMITED
Patent: WO2009/7995 A1, 2009 ;
Location in patent: Page/Page column 11; 17 ;
参考文献
Nair, Divya K.; Mobin, Shaikh M.; Namboothiri, Irishi N.N.
Organic Letters, 2012 , vol. 14, # 17 p. 4580 - 4583
反应条件
thionyl chloride in methanol T=0°C; 2 h;
参考文献
SEPRACOR, INC.; FANG, Kevin; GROVER, Paul; JERUSSI, Tom
Patent: WO2005/44818 A2, 2005 ;
Location in patent: Page/Page column 42-43 ;
WO 2005/044818 A2
反应条件
1: With sulfuric acid T=5 - 20°C; 4 h; Heating / reflux; 2: With sodium carbonate in water pH=8; Product distribution / selectivity;
参考文献
EGIS GYOGYSZERGYAR RT.
Patent: EP1259509 B1, 2005 ;
Location in patent: Page/Page column 7 ;
