1-苯磺酰基-1H-吡咯并[2,3-b]吡啶-2-羧酸合成路线 （共 6 条）
反应条件
1: 1-(benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine With lithium diisopropyl amide in tetrahydrofuran T=-35°C; 0.5 h; 2: carbon dioxide T=-35 - 20°C; 12 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 3 p. 1019 - 1022
反应条件
sodium chlorite; sodium dihydrogenphosphate in tert-butyl benzene; 2-methyl-butane 3.16667 h;
参考文献
WO2006/50976 A1, ;
Page/Page column 30 ;
WO 2006/050976 A1
反应条件
1: 94 percent / NaOH, benzyltriethylammonium chloride / CH2Cl2 / 1) 0 deg C, 15 min; 2) rt, 2 h 2: 1.) lithium diisopropylamide / 1) THF, -25 deg C, 30 min; 2) THF View Scheme
参考文献
Tetrahedron, , vol. 53, # 10 p. 3637 - 3648
反应条件
1: 94 percent / NaOH, benzyltriethylammonium chloride / CH2Cl2 / 1) 0 deg C, 15 min; 2) rt, 2 h 2: 1.) lithium diisopropylamide / 1) THF, -25 deg C, 30 min; 2) THF View Scheme
参考文献
Tetrahedron, , vol. 53, # 10 p. 3637 - 3648
反应条件
sodium t-butanolate in 1,4-dioxane T=80°C; 3 h; Inert atmosphere;
参考文献
Chaulet, Charlotte; Croix, Cecile; Basset, Joan; Pujol, Maria-Dolores; Viaud-Massuard, Marie-Claude
Synlett, 2010 , # 10 p. 1481 - 1484
反应条件
sulfuric acid 12 h; Reflux;
参考文献
Chaulet, Charlotte; Croix, Cecile; Alagille, David; Normand, Sylvain; Delwail, Adriana; Favot, Laure; Lecron, Jean-Claude; Viaud-Massuard, Marie-Claude
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 3 p. 1019 - 1022
