2-甲基-2-丙基(4-碘苄基)氨基甲酸酯合成路线 （共 8 条）
反应条件
sodium hydroxide in 1,4-dioxane; water T=20°C; 18 h;
参考文献
CENGENT THERAPEUTICS, INC.
Patent: WO2006/9876 A2, 2006 ;
Location in patent: Page/Page column 139 ;
WO 2006/009876 A2
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 2 h;
参考文献
METHYLGENE INC.
Patent: WO2006/102760 A1, 2006 ;
Location in patent: Page/Page column 129 ;
反应条件
1: 1-(azidomethyl)-4-iodobenzene With water; triphenylphosphine in tetrahydrofuran T=20°C; 2: di-tert-butyl dicarbonate With triethylamine in tetrahydrofuran T=20°C; 3 h;
参考文献
Lee, Jeewoo; Kang, Sang-Uk; Lim, Ju-Ok; Choi, Hyun-Kyung; Jin, Mi-Kyung; Toth, Attila; Pearce, Larry V.; Tran, Richard; Wang, Yun; Szabo, Tamas; Blumberg, Peter M.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 2 p. 371 - 385
反应条件
triethylamine in tetrahydrofuran T=20°C; Inert atmosphere;
参考文献
Guenbas, D. Deniz; Brouwer, Albert M.
Journal of Organic Chemistry, 2012 , vol. 77, # 13 p. 5724 - 5735
反应条件
triethylamine in tetrahydrofuran T=20°C; 3 h;
参考文献
Ki, Duk Park; Morieux, Pierre; Salome, Christophe; Cotten, Steven W.; Reamtong, Onrapak; Eyers, Claire; Gaskell, Simon J.; Stables, James P.; Liu, Rihe; Kohn, Harold
Journal of Medicinal Chemistry, 2009 , vol. 52, # 21 p. 6897 - 6911
反应条件
1: aq. ammonia / 120 h / 20 °C 2: 0.24 g / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Lee, Jeewoo; Kang, Sang-Uk; Lim, Ju-Ok; Choi, Hyun-Kyung; Jin, Mi-Kyung; Toth, Attila; Pearce, Larry V.; Tran, Richard; Wang, Yun; Szabo, Tamas; Blumberg, Peter M.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 2 p. 371 - 385
反应条件
1: 70 percent / N-methylmorpholine; isobutyl chloroformate; NaBH4 / tetrahydrofuran; methanol / 0.5 h / -10 - 0 °C 2: 58 percent / PBr3 / diethyl ether / 3 h / 0 - 20 °C 3: aq. ammonia / 120 h / 20 °C 4: 0.24 g / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Vassiliou, Stamatia; Xeilari, Metaxia; Yiotakis, Athanasios; Grembecka, Jolanta; Pawelczak, Malgorzata; Kafarski, Pawel; Mucha, Artur
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 9 p. 3187 - 3200
反应条件
1: 58 percent / PBr3 / diethyl ether / 3 h / 0 - 20 °C 2: aq. ammonia / 120 h / 20 °C 3: 0.24 g / CH2Cl2 / 15 h / 20 °C View Scheme
参考文献
Vassiliou, Stamatia; Xeilari, Metaxia; Yiotakis, Athanasios; Grembecka, Jolanta; Pawelczak, Malgorzata; Kafarski, Pawel; Mucha, Artur
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 9 p. 3187 - 3200
