4-(甲基磺酰基)-哌啶-1-羧酸叔丁酯合成路线 (共 8 条)
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=0 - 20°C;
参考文献
EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
Location in patent: Page/Page column 158 ;
WO 2012/071509 A2
反应条件
triethylamine in dichloromethane T=0 - 20°C; Product distribution / selectivity;
参考文献
Piramed Limited; Genentech, Inc.
Patent: US2008/76758 A1, 2008 ;
Location in patent: Page/Page column 86 ;
US 20080076758 A1
反应条件
1: triethylamine / dichloromethane / 2.17 h / 0 - 20 °C 2: methanol / 15 h / Reflux 3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 0 - 20 °C View Scheme
参考文献
EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
WO 2012/071509 A2
反应条件
1: methanol / 15 h / Reflux 2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 15 h / 0 - 20 °C View Scheme
参考文献
EXELIXIS, INC.; RICE, Kenneth
Patent: WO2012/71509 A2, 2012 ;
WO 2012/071509 A2
反应条件
1: 4-Iodopyrazole With sodium hydride in N,N-dimethyl-formamide T=0°C; 1 h; 2: 4-methanesulfonylpiperidine-1-carboxylic acid tert-butyl ester in N,N-dimethyl-formamide T=100°C; 16 h;
参考文献
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; MOOKHTIAR, Kasim; KURHADE, Santosh; MUNOT, Yogesh
Patent: WO2013/157022 A1, 2013 ;
Location in patent: Page/Page column 56-57 ;
反应条件
hydrogenchloride in 1,4-dioxane; ethyl acetate 3 h;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1642880 A1, 2006 ;
Location in patent: Page/Page column 112 ;
反应条件
1: NaH / dimethylformamide / 90 °C
2: H2 / Pd/C / tetrahydrofuran / 7 h / 20 °C / 3102.89 Torr
3: 75 percent / Et3N / tetrahydrofuran / 20 °C
4: 97 percent / TFA / CH2Cl2
View Scheme
参考文献
Zhang, Deyi; Kohlman, Dan; Krushinski, Joseph; Liang, Sidney; Ying, Bai-Ping; Reilly, John E.; Dinn, Sean R.; Wainscott, David B.; Nutter, Suzanne; Gough, Wendy; Nelson, David L.G.; Schaus, John M.; Xu, Yao-Chang
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 24 p. 6011 - 6016
反应条件
hydrogenchloride in ethyl acetate
T=0 - 20°C;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1486490 A1, 2004 ;
Location in patent: Page 46 ;