2,6-二氯-5-氟烟酸甲酯合成路线 （共 4 条）
反应条件
1: 2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 1 h; 2: methanol in dichloromethane T=20°C; 2 h;
参考文献
WO2010/126851 A1, ;
Page/Page column 108-109 ;
WO 2010/126851 A1
反应条件
potassium carbonate in methanol; dichloromethane; chloroform; N,N-dimethyl-formamide
反应条件
methanol T=20°C; 0.666667 h;
参考文献
TOYAMA CHEMICAL CO., LTD.; Taisho Pharmaceutical Co. Ltd.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 72 ;
Title/Abstract Full Text Show Details
Taisho Pharmaceutical Co. Ltd.; TOYAMA CHEMICAL CO., LTD.
Patent: EP2022793 A1, 2009 ;
Location in patent: Page/Page column 72 ;
EP 2022793 A1
反应条件
diisobutylaluminium hydride in dichloromethane; toluene
T=0°C; Inert atmosphere;
参考文献
Alemparte-Gallardo, Carlos; Barfoot, Christopher; Barros-Aguirre, David; Cacho-Izquierdo, Monica; Fiandor Roman, Jose Maria; Hennessy, Alan Joseph; Pearson, Neil David; Remuinan-Blanco, Modesto Jesus
Patent: US2009/306089 A1, 2009 ;
Location in patent: Page/Page column 27 ;
