二乙基2-[4-(2,2-二乙氧羰基丙基)苯基]-2-甲基丙二酸酯合成路线 （共 4 条）
反应条件
1: 2-(4-ethoxycarbonylmethyl-benzyl)-2-methyl-malonic acid diethyl ester; carbonic acid diethyl ester With sodium in ethanol T=100°C; Condensation; 0.833333 h; 2: methyl iodide in ethanol T=20°C; Methylation; 1 h;
参考文献
Shyadehi, Akbar Z.; Harding, John J.
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 3 p. 207 - 213
反应条件
1.1: 68.3 percent / sodium / ethanol / 0.5 h / 20 °C 2.1: conc. H2SO4 3.1: sodium / ethanol / 0.83 h / 100 °C 3.2: 5.3 g / ethanol; various solvent(s) / 1 h / 20 °C View Scheme
参考文献
Shyadehi, Akbar Z.; Harding, John J.
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 3 p. 207 - 213
反应条件
1.1: 68.3 percent / sodium / ethanol / 0.5 h / 20 °C 2.1: conc. H2SO4 3.1: sodium / ethanol / 0.83 h / 100 °C 3.2: 5.3 g / ethanol; various solvent(s) / 1 h / 20 °C View Scheme
参考文献
Shyadehi, Akbar Z.; Harding, John J.
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 3 p. 207 - 213
反应条件
1.1: conc. H2SO4 2.1: sodium / ethanol / 0.83 h / 100 °C 2.2: 5.3 g / ethanol; various solvent(s) / 1 h / 20 °C View Scheme
参考文献
Shyadehi, Akbar Z.; Harding, John J.
Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 3 p. 207 - 213
