9-氧代-3-氮杂螺[5.5]-7-十一烯-3-羧酸苄酯合成路线 （共 3 条）
反应条件
1: With toluene-4-sulfonic acid in benzene T=70°C; 24 h; Reflux; 2: With sodium hydrogencarbonate in water; benzene T=20°C;
参考文献
PFIZER INC.
Patent: US2012/270893 A1, 2012 ;
Location in patent: Page/Page column 17-18 ;
反应条件
hydrogen; palladium on activated charcoal
参考文献
Pandey; Seroogy; Volkots; Smyth; Rose; Mehrotra; Heath; Ruhter; Schotten; Scarborough
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1293 - 1296
反应条件
palladium on activated charcoal; hydrogen; triethylamine in methanol
5 h;
参考文献
Boivin, Roch; Carlson, Eric; Endo, Atsushi; Hansen, Hans; Hawkins, Lynn D.; Ishizaka, Sally; Mackey, Matthew; Narayan, Sridhar; Satoh, Takashi; Schiller, Shawn
Patent: US2013/324547 A1, 2013 ;
Location in patent: Paragraph 0500 ;
