2,4-二氧代-9-苯甲基-3,9-二氮杂螺[5.5]十一烷-1,5-二甲腈合成路线 (共 3 条)
反应条件
ammonium acetate; ammonia in water T=5°C; Product distribution / selectivity;
参考文献
NEUROGEN CORPORATION; XU, Yuelian; XIE, Linghong; HAN, Bingsong; MAYNARD, George D.; CHENARD, Bertrand, L.; STAAB, Andrew J.
Patent: WO2009/97405 A2, 2009 ;
Location in patent: Page/Page column 16; 17 ;
反应条件
1: aq. H2SO4 / 8.5 h / Heating 2: H2SO4 / 14 h / Heating View Scheme
参考文献
Leonardi, Amedeo; Barlocco, Daniela; Montesano, Federica; Cignarella, Giorgio; Motta, Gianni; Testa, Rodolfo; Poggesi, Elena; Seeber, Michele; De Benedetti, Pier G.; Fanelli, Francesca
Journal of Medicinal Chemistry, 2004 , vol. 47, # 8 p. 1900 - 1918
反应条件
sulfuric acid in water 2 h; Heating / reflux;
参考文献
NEUROGEN CORPORATION
Patent: WO2007/140383 A2, 2007 ;
Location in patent: Page/Page column 53 ;
WO 2007/140383 A2