1: 2,6-lutidine / CH2Cl2 / 0 - 20 °C 2: 2N NaOH / tetrahydrofuran / 1 h / 20 °C 3: 51 percent / toluene; tetrahydrofuran / -45 - 20 °C View Scheme

1.1: 90 percent / 2,6-lutidine / CH2Cl2 / 0 - 25 °C 2.1: 95 percent / 10percent NaOH / tetrahydrofuran / 0.5 h / 20 °C 3.1: NaOCH3 / acetonitrile / Heating 3.2: conc. HCl / Heating View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605283', constants.ctx, '0')">triethylamine</a> <br /> <br /> &nbsp;