1: With potassium carbonate in tetrahydrofuran; water T=20°C; 2 h; 2: With hydrogenchloride in water T=0°C; pH=3;

1: With potassium carbonate in tetrahydrofuran; water T=20°C; 2 h; 2: With hydrogenchloride in water T=0°C; pH=3;

1: (R)-2-tert-butoxycarbonylamino-3-((R)-2-tert-butoxycarbonylamino-2-carboxy-ethyldisulfanyl)-propionic acid With sodium tetrahydroborate in ethanol 0.25 h; Inert atmosphere; 2: p-methoxybenzyl chloride in ethanol Inert atmosphere;

triethylamine in 1,4-dioxane; water 3 h;

暂无反应条件数据

1.1: 1,4-dioxane; water 2.1: sodium tetrahydroborate / ethanol / 0.25 h / Inert atmosphere 2.2: Inert atmosphere View Scheme

1: Et3SiH, TFA / CH2Cl2 / Ambient temperature 2: tetrahydrofuran; H2O / Ambient temperature; pH=8 View Scheme

1: C16H22NO4PolS With 3-methyl-phenol; trifluoroacetic acid 0.25 h; Automated synthesizersolid phase reaction; 2: N-tert-butoxycarbonyl-O-benzyl-L-serine With 1-methyl-pyrrolidin-2-one; benzotriazol-1-ol; diisopropyl-carbodiimide 1 h; Automated synthesizersolid phase reaction; 3: BOC-glycine; N-tert-butoxycarbonyl-L-alanine; N-tert-butoxycarbonyl-L-phenylalanine; N-Boc-L-threonine benzyl ether; BOC-S-4-methoxybenzyl-L-cysteine; N6-[[(2-Chlorophenyl)methoxy]carbonyl]-N2-[t-butyloxycarbonyl]-L-lysine; N-(tert-butoxycarbonyl)-L-tryptophan; Boc-Asn(Xan)-OH Further stages;

silver tetrafluoroborate; methoxybenzene in trifluoroacetic acid

in dichloromethane T=0°C; 0.5 h;