Epothilone D合成路线 （共 263 条）
反应条件
1: 99 percent / Dess-Martin periodinane 2: 74 percent / n-BuLi 3: DIBAL-H 4: Dess-Martin periodinane 5: 67 percent / Li(i-Pr)2N / -78 °C 6: 79 percent / Cl2CHCO2H 7: Dess-Martin periodinane 8: NaClO2 9: MgBr2; n-BuSH; K2CO3 10: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 11: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
反应条件
1: 74 percent / n-BuLi 2: DIBAL-H 3: Dess-Martin periodinane 4: 67 percent / Li(i-Pr)2N / -78 °C 5: 79 percent / Cl2CHCO2H 6: Dess-Martin periodinane 7: NaClO2 8: MgBr2; n-BuSH; K2CO3 9: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 10: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
反应条件
1: Dess-Martin periodinane 2: 99 percent / Dess-Martin periodinane 3: 74 percent / n-BuLi 4: DIBAL-H 5: Dess-Martin periodinane 6: 67 percent / Li(i-Pr)2N / -78 °C 7: 79 percent / Cl2CHCO2H 8: Dess-Martin periodinane 9: NaClO2 10: MgBr2; n-BuSH; K2CO3 11: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 12: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
反应条件
1.1: Bu3SnH; AIBN 1.2: SnBr4 / -78 °C 2.1: 80 percent / pyridine 3.1: 59 percent / Bu3SnH; AIBN 4.1: 91 percent / DDQ 5.1: 97 percent / Bu4NF 6.1: Dess-Martin periodinane 7.1: 99 percent / Dess-Martin periodinane 8.1: 74 percent / n-BuLi 9.1: DIBAL-H 10.1: Dess-Martin periodinane 11.1: 67 percent / Li(i-Pr)2N / -78 °C 12.1: 79 percent / Cl2CHCO2H 13.1: Dess-Martin periodinane 14.1: NaClO2 15.1: MgBr2; n-BuSH; K2CO3 16.1: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 17.1: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
反应条件
1: 97 percent / Bu4NF 2: Dess-Martin periodinane 3: 99 percent / Dess-Martin periodinane 4: 74 percent / n-BuLi 5: DIBAL-H 6: Dess-Martin periodinane 7: 67 percent / Li(i-Pr)2N / -78 °C 8: 79 percent / Cl2CHCO2H 9: Dess-Martin periodinane 10: NaClO2 11: MgBr2; n-BuSH; K2CO3 12: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 13: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
反应条件
1: 89 percent / Dess-Martin periodinane 2: 67 percent / Li(i-Pr)2N / -78 °C 3: 79 percent / Cl2CHCO2H 4: Dess-Martin periodinane 5: NaClO2 6: MgBr2; n-BuSH; K2CO3 7: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 8: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
反应条件
1: 67 percent / Li(i-Pr)2N / -78 °C 2: 79 percent / Cl2CHCO2H 3: Dess-Martin periodinane 4: NaClO2 5: MgBr2; n-BuSH; K2CO3 6: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 7: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
反应条件
1: 97 percent / Bu4NF 2: Dess-Martin periodinane 3: 99 percent / Dess-Martin periodinane 4: 74 percent / n-BuLi 5: DIBAL-H 6: Dess-Martin periodinane 7: 67 percent / Li(i-Pr)2N / -78 °C 8: 79 percent / Cl2CHCO2H 9: Dess-Martin periodinane 10: NaClO2 11: MgBr2; n-BuSH; K2CO3 12: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 13: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
反应条件
1: DIBAL-H 2: Dess-Martin periodinane 3: 67 percent / Li(i-Pr)2N / -78 °C 4: 79 percent / Cl2CHCO2H 5: Dess-Martin periodinane 6: NaClO2 7: MgBr2; n-BuSH; K2CO3 8: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 9: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
反应条件
1: 91 percent / DDQ 2: 97 percent / Bu4NF 3: Dess-Martin periodinane 4: 99 percent / Dess-Martin periodinane 5: 74 percent / n-BuLi 6: DIBAL-H 7: Dess-Martin periodinane 8: 67 percent / Li(i-Pr)2N / -78 °C 9: 79 percent / Cl2CHCO2H 10: Dess-Martin periodinane 11: NaClO2 12: MgBr2; n-BuSH; K2CO3 13: 62 percent / 2,4,6-trichlorobenzoyl chloride; DMAP 14: 91 percent / CF3CO2H / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 47 p. 8373 - 8377
