二氟氯乙酸钠合成路线

参考文献

Bhadury, Pinaki S.; Palit, Meehir; Sharma, Mamta; Raza, Syed K.; Jaiswal, Devendra K.
Journal of Fluorine Chemistry, 2002 , vol. 116, # 1 p. 75 - 80

106-41-24-溴苯酚+

1895-39-2二氟氯乙酸钠

5905-69-11-溴-4-(二氟甲氧基)苯

参考文献

Sifferlen, Thierry; Koberstein, Ralf; Cottreel, Emmanuelle; Boller, Amandine; Weller, Thomas; Gatfield, John; Brisbare-Roch, Catherine; Jenck, Francois; Boss, Christoph
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 13 p. 3857 - 3863

参考文献

Mitchell, William L.; Ravenscroft, Paul; Hill, Malcolm L.; Knutsen, Lars J.S.; Judkins, Brian D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 809 - 816

1895-39-2二氟氯乙酸钠+

97776-66-4

100244-27-7

参考文献

Mitchell, William L.; Ravenscroft, Paul; Hill, Malcolm L.; Knutsen, Lars J.S.; Judkins, Brian D.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 809 - 816

621-59-03-羟基-4-甲氧基苯甲醛+

1895-39-2二氟氯乙酸钠

153587-11-23-二氟甲氧基-4-甲氧基苯甲醛

参考文献

ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; BROTSCHI, Christine; KOBERSTEIN, Ralf; SIEGRIST, Romain; SIFFERLEN, Thierry; TRACHSEL, Daniel; WILLIAMS, Jodi T.
Patent: WO2010/44054 A1, 2010 ;
Location in patent: Page/Page column 108-109 ;
WO 2010/044054 A1

1895-39-2二氟氯乙酸钠

75-10-5二氟甲烷

参考文献

Bhadury, Pinaki S.; Palit, Meehir; Sharma, Mamta; Raza, Syed K.; Jaiswal, Devendra K.
Journal of Fluorine Chemistry, 2002 , vol. 116, # 1 p. 75 - 80

1895-39-2二氟氯乙酸钠+

139-85-5原儿茶醛

127842-54-03,4-双(二氟甲氧基)苯甲醛

参考文献

WO2006/76246 A2, ;

Page/Page column 220 ;
WO 2006/076246 A2

394-59-24-(三氟乙酰基)甲苯+

1895-39-2二氟氯乙酸钠

35462-71-6

参考文献

Klabunde,K.J.; Burton,D.J.
Journal of the American Chemical Society, 1972 , vol. 94, p. 820 - 828

100-02-7对硝基苯酚+

1895-39-2二氟氯乙酸钠

1544-86-14-(二氟甲氧基)硝基苯

参考文献

SmithKline Beecham Corporation
Patent: US5731477 A1, 1998 ;

1895-39-2二氟氯乙酸钠+

139-85-5原儿茶醛

151103-08-14-二氟甲氧基-3-羟基苯甲醛

参考文献

Armani, Elisabetta; Amari, Gabriele; Rizzi, Andrea; Fanti, Renato De; Ghidini, Eleonora; Capaldi, Carmelida; Carzaniga, Laura; Caruso, Paola; Guala, Matilde; Peretto, Ilaria; La Porta, Elena; Bolzoni, Pier T.; Facchinetti, Fabrizio; Carnini, Chiara; Moretto, Nadia; Patacchini, Riccardo; Bassani, Franco; Cenacchi, Valentina; Volta, Roberta; Amadei, Francesco; Capacchi, Silvia; Delcanale, Maurizio; Puccini, Paola; Catinella, Silvia; Civelli, Maurizio; Villetti, Gino
Journal of Medicinal Chemistry, 2014 , vol. 57, # 3 p. 793 - 816