3-氨基-2-甲基-4(3H)喹唑啉酮合成路线 （共 61 条）
参考文献
Fleita, Daisy H.; Mohareb, Rafat M.; Sakka, Ola K.
Medicinal Chemistry Research, 2013 , vol. 22, # 5 p. 2207 - 2221
反应条件
in benzene
4 h; Heating;
参考文献
Agarwal, Rajesh; Chaudhary, Chapla; Misra, V. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 12 p. 1110 - 1113
反应条件
1: 76 percent / ethanol / 2 h / Heating
2: 61 percent / POCl3 / 5 h / 55 - 60 °C
3: 68 percent / ethanol / 1.) room temp., 2.) warmed, 30 min
View Scheme
参考文献
Barnela, S. B.; Seshadri, S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1984 , vol. 23, # 2 p. 161 - 162
反应条件
in ethanol
6 h; Heating;
参考文献
El-Feky
Pharmazie, 1993 , vol. 48, # 12 p. 894 - 896
反应条件
1: sodium hydroxide / dimethylsulfoxide / 1 h / 20 °C
2: dimethylsulfoxide / 2 h / 5 - 10 °C
3: 72 percent / dimethylformamide / 19 h / Heating
View Scheme
参考文献
Alagarsamy, Veerachamy; Murugananthan, Gopal; Venkateshperumal, Ramachandran
Biological and Pharmaceutical Bulletin, 2003 , vol. 26, # 12 p. 1711 - 1714
反应条件
pyridine in benzene
2 h; Heating;
参考文献
Ibrahim, S. S.; Abdel-Halim, A. M.; Gabr, Y.; El-Edfawy, S.; Abdel-Rahman, R. M.
Journal of Chemical Research, Miniprint, 1997 , # 5 p. 1041 - 1063
反应条件
triethylamine; trichlorophosphate in toluene
0.75 h; Heating;
参考文献
Ossman, Abdel Rahman El Nasser; Safwat, H. M.; Aziza, Mohsen A.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1985 , vol. 24, p. 333 - 335
反应条件
1: 68 percent / acetic acid / 4 h / Heating
2: 70 percent / NaOH / H2O / Heating
View Scheme
参考文献
Archana; Srivastava; Chandra, Ramesh; Kumar, Ashok
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 11 p. 2371 - 2375
反应条件
methyllithium
1) THF, -20 deg C, 30 min; 2) THF, -78 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Smith, Keith; El-Hiti, Gamal A.; Abdel-Megeed, Mohamed F.; Abdo, Mohamed A.
Journal of Organic Chemistry, 1996 , vol. 61, # 2 p. 656 - 661
反应条件
in ethanol
3 h; Heating;
参考文献
Yassin, F. A.; Eissa, A. M. F.; Wasfy, A. A. F.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, p. 1193 - 1196
