2-氯-4-甲氧基-6-甲基-5-硝基嘧啶合成路线 （共 4 条）
反应条件
1: in methanol T=-10°C; 0.166667 h; 2: With acetic acid in methanol
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/99688 A2, 2005 ;
Location in patent: Page/Page column 145-146 ;
WO 2005/099688 A2
反应条件
in methanol T=0°C; 0.25 h;
参考文献
Cupps, Thomas L.; Wise, Dean S.; Townsend, Leroy B.
Journal of Organic Chemistry, 1983 , vol. 48, # 7 p. 1060 - 1064
反应条件
1: 60 percent / POCl3; PhNEt2 / Heating 2: 35 percent / methanol View Scheme
参考文献
Hodgetts, Kevin J.; Yoon, Taeyoung; Huang, Jianhua; Gulianello, Michael; Kieltyka, Andrzej; Primus, Renee; Brodbeck, Robbin; De Lombaert, Stephane; Doller, Dario
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2497 - 2500
反应条件
1: 75 percent / KNO3; H2SO4 2: 60 percent / POCl3; PhNEt2 / Heating 3: 35 percent / methanol View Scheme
参考文献
Hodgetts, Kevin J.; Yoon, Taeyoung; Huang, Jianhua; Gulianello, Michael; Kieltyka, Andrzej; Primus, Renee; Brodbeck, Robbin; De Lombaert, Stephane; Doller, Dario
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2497 - 2500
