N1-(3,5-bis(trifluoromethyl)phenyl)-N3-((1R,2R)-2-(dimethylamino)cyclohexyl)benzene-1,3-disulfonamide in toluene T=20°C; 240 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;

C32H28F6N4O2 in dichloromethane T=20°C; 7 h;

acetic acid 3,5-diacetoxy-2-acetoxymethyl-6-[3-(2-dimethylamino-cyclohexyl)-thioureido]-tetrahydro-pyran-4-yl ester in toluene T=-40°C; Michael condensation; 23 h; enantiospecific reaction;

(1R,2R)-1-[[3',5'-(CF3)2-C6H3]-NH-C(S)-NH]-2-NMe2-cC6H10 in toluene T=20°C; Michael addition; 1 h; Title compound not separated from byproducts.;