polystyrene-supported CuI-imidazole complex catalyst in N,N-dimethyl-formamide T=75°C; Aza-Michael reaction; 6 h;

1: 2-methyl-1H-imidazole With tetrabutylammomium bromide; potassium carbonate; potassium hydroxide in dichloromethane T=20°C; 0.5 h; 2: 3-(bromo)propionic acid ethyl ester in dichloromethane T=20°C; Reflux;

hydrogenchloride; water 8 h; Reflux;