4-氧代哌啶-1-羧酸异丙酯合成路线 （共 3 条）
反应条件
triethylamine in dichloromethane T=20°C; 1 h; Cooling with ice;
参考文献
Mitsubishi Tanabe Pharma Corporation
Patent: EP2390254 A1, 2011 ;
Location in patent: Page/Page column 64 ;
EP 2390254 A1
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With trifluoroacetic acid in dichloromethane T=20°C; 18.16 h; 2: isopropyloxycarbonylchloride With triethylamine in dichloromethane; toluene T=20°C; 2.08 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2008/137436 A1, 2008 ;
Location in patent: Page/Page column 85-86 ;
WO 2008/137436 A1
反应条件
1: triethylamine / dichloromethane; toluene / 0 - 20 °C / |Inert atmosphere 2: hydrogenchloride / water / 20 °C View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; NEUROCRINE BIOSCIENCES, INC.; NOSSE, Bernd; ECKHARDT, Matthias; HIMMELSBACH, Frank; LANGKOPF, Elke; ASHWEEK, Neil J.; HARRIOTT, Nicole
Patent: WO2014/19967 A1, 2014 ;
