4-二甲氨基-3-硝基苯甲腈合成路线 （共 9 条）
反应条件
1: NaOH-solution; alcohol 2: potassium permanganate; natrium carbonate View Scheme
参考文献
Noelting; Demant
Chemische Berichte, 1904 , vol. 37, p. 1029
反应条件
1: NaOH-solution; alcohol 2: potassium permanganate; natrium carbonate 3: concentrated sulfuric acid View Scheme
参考文献
Noelting; Demant
Chemische Berichte, 1904 , vol. 37, p. 1029
反应条件
1: N,N-dimethyl-formamide With ammonia in water
T=240°C; 0.666667 h;
2: 2-chloro-5-cyano-1-nitrobenzene in water
0.333333 h;
参考文献
Petersen, Trine P.; Larsen, Anders Foller; Ritzen, Andreas; Ulven, Trond
Journal of Organic Chemistry, 2013 , vol. 78, # 8 p. 4190 - 4195
反应条件
1: 4-amino-3-nitro-benzonitrile With sodium hydride in N,N-dimethyl-formamide; mineral oil
T=0°C; 0.5 h;
2: methyl iodide in N,N-dimethyl-formamide; mineral oil
T=20°C; 1.5 h;
参考文献
Jin, Cheng Hua; Krishnaiah, Maddeboina; Sreenu, Domalapally; Subrahmanyam, Vura B.; Rao, Kota S.; Lee, Hwa Jeong; Park, So-Jung; Park, Hyun-Ju; Lee, Kiho; Sheen, Yhun Yhong; Kim, Dae-Kee
Journal of Medicinal Chemistry, 2014 , vol. 57, # 10 p. 4213 - 4238
反应条件
ethanol
T=150°C; im Rohr;
参考文献
Mattaar
Recueil des Travaux Chimiques des Pays-Bas, 1922 , vol. 41, p. 36
反应条件
in ethanol
T=20°C; Condensation;
参考文献
Makosza; Voskresensky; Bialecki; Kwast
Polish Journal of Chemistry, 1999 , vol. 73, # 12 p. 1969 - 1977
反应条件
1: alkali; hydroxylamine hydrochloride
2: acetic acid anhydride; sodium acetate
View Scheme
参考文献
Noelting; Demant
Chemische Berichte, 1904 , vol. 37, p. 1029
反应条件
2: nitric acid
3: alcohol / 150 °C / im Rohr
View Scheme
参考文献
Mattaar
Recueil des Travaux Chimiques des Pays-Bas, 1922 , vol. 41, p. 36
反应条件
sodium hydroxide; ethanol
参考文献
Noelting; Demant
Chemische Berichte, 1904 , vol. 37, p. 1029
