2-甲基-1,3-噻唑烷-4-羧酸合成路线 （共 4 条）
反应条件
potassium acetate in ethanol; water T=20°C; 48 h;
参考文献
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CRYSTAL GENOMICS, INC.
Patent: WO2008/117982 A1, 2008 ;
Location in patent: Page/Page column 61 ;
参考文献
Nagasawa; Goon; Muldoon; Zera
Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 591 - 596
反应条件
ethanol; sodium hydrogencarbonate
参考文献
Howard-Lock, H. E.; Lock, C. J. L.; Martins, M. L.; Smalley, P. S.; Bell, R. A.
Canadian Journal of Chemistry, 1986 , vol. 64, p. 1215 - 1219
反应条件
1: triethylamine; isobutylchloroformate / 1.) THF, -15 deg C, 3 h; 2.) rt, 20-24 h 2: 75 percent / hydrogen bromide in acetic acid / Ambient temperature View Scheme
参考文献
Aboulwafa; Oiry; Imbach; Fatome
European Journal of Medicinal Chemistry, 1986 , vol. 21, # 6 p. 493 - 497
