2-苯基-1H-吲哚-5-羧酸甲酯合成路线 （共 13 条）
反应条件
1: 6.5 g / BTMA-ICl2 / acetic acid; CH2Cl2
2: 6.2 g / acetic acid
4: 95 percent / tetramethylguanidine, CuI / Pd(Ph3P)2Cl2 / dioxane / 18 h / 80 °C
View Scheme
参考文献
Fagnola, Maria Chiara; Candiani, Ilaria; Visentin, Giuseppina; Cabri, Walter; Zarini, Franco; Mongelli, Nicola; Bedeschi, Angelo
Tetrahedron Letters, 1997 , vol. 38, # 13 p. 2307 - 2310
反应条件
[Rh(coe)2Cl]2; Cs(OPiv)2; tris(4-trifluoromethylphenyl)phosphine in 1,4-dioxane
T=120°C;
参考文献
Ambrus, Joseph I.; Kelso, Michael J.; Bremner, John B.; Ball, Anthony R.; Casadei, Gabriele; Lewis, Kim
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 15 p. 4294 - 4297
反应条件
1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere
2: potassium carbonate; L-proline; copper(I) bromide / dimethyl sulfoxide / 3 h / 100 °C / Inert atmosphere
View Scheme
参考文献
Ponpandian, Thanasekaran; Muthusubramanian, Shanmugam
Tetrahedron Letters, 2012 , vol. 53, # 32 p. 4248 - 4252
