乙基 4-甲基-3-硝基苯甲酸合成路线 （共 11 条）
反应条件
hydrogenchloride T=90°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong
Patent: WO2011/71716 A1, 2011 ;
Location in patent: Page/Page column 39-40 ;
WO 2011/071716 A1
参考文献
US6087380 A1, ;
US 6087380 A
参考文献
Desrousseaux; Bennetau; Morand; Mingotaud; Letard; Montant; Freysz
New Journal of Chemistry, 2000 , vol. 24, # 12 p. 977 - 985
反应条件
sulfuric acid; nitric acid T=0°C;
参考文献
Journal of the Chinese Chemical Society (Peking), , vol. 14, p. 31,35
反应条件
1: thionyl chloride / 3 h / Heating 2: 95 percent / 8 h / Heating View Scheme
参考文献
New Journal of Chemistry, , vol. 24, # 12 p. 977 - 985
反应条件
1: 100 percent / SnCl2*2H2O / ethanol / 0.5 h / 70 °C 2: 1.) aq. NaNO2, 48percent aq. HBr, 2.) CuBr, 48percent aq. HBr / 1.) -5 deg C, 5 min, 2.) 70 deg C, 1 h View Scheme
参考文献
Gilbert, Adam M.; Katz, Thomas J.; Geiger, William E.; Robben, Matthew P.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3199 - 3211
反应条件
tin(ll) chloride in ethanol T=70°C; 0.5 h;
参考文献
Gilbert, Adam M.; Katz, Thomas J.; Geiger, William E.; Robben, Matthew P.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3199 - 3211
反应条件
1.1: sodium ethanolate / ethanol / 16 h / 20 °C 1.2: pH 7 2.1: zinc; acetic acid / water / 1 h / 85 °C View Scheme
参考文献
WO2011/71716 A1, ;
WO 2011/071716 A1
参考文献
Sah; Wang
Journal of the Chinese Chemical Society (Peking), 1946 , vol. 14, p. 31,35
反应条件
1: 100 percent / SnCl2*2H2O / ethanol / 0.5 h / 70 °C
2: 1.) aq. NaNO2, 48percent aq. HBr, 2.) CuBr, 48percent aq. HBr / 1.) -5 deg C, 5 min, 2.) 70 deg C, 1 h
3: 61 percent / N-bromosuccinimide, benzoyl peroxide / CCl4 / 10 h / Heating
View Scheme
参考文献
Gilbert, Adam M.; Katz, Thomas J.; Geiger, William E.; Robben, Matthew P.; Rheingold, Arnold L.
Journal of the American Chemical Society, 1993 , vol. 115, # 8 p. 3199 - 3211
