(3S)-3-[(叔丁氧羰基)氨基]-3-苯基丙酸甲酯合成路线 （共 32 条）
反应条件
sodium hydrogencarbonate
参考文献
Price, David A.; Gayton, Simon; Selby, Matthew D.; Ahman, Jens; Haycock-Lewandowski, Sarah; Stammen, Blanda L.; Warren, Andrew
Tetrahedron Letters, 2005 , vol. 46, # 30 p. 5005 - 5007
反应条件
(R,S)-tert-butyl Josiphos; hydrogen; [Ph(COD)Cl]2 in methanol T=20°C; P=4654.33 - 5171.48 Torr; 18 h;
参考文献
Hansen, Karl B.; Rosner, Thorsten; Kubryk, Michele; Dormer, Peter G.; Armstrong III, Joseph D.
Organic Letters, 2005 , vol. 7, # 22 p. 4935 - 4938
反应条件
1: (S)-3-methoxyamino-3-phenylpropionic acid methyl ester With hydrogen; palladium on activated charcoal in methanol T=20°C; P=760 Torr; 2: di-tert-butyl dicarbonate in methanol 6 h;
参考文献
Journal of the American Chemical Society, , vol. 127, # 38 p. 13419 - 13427
反应条件
potassium carbonate in N,N-dimethyl-formamide
反应条件
sodium carbonate in dichloromethane; water T=20°C; 3 h;
参考文献
Abrunhosa-Thomas, Isabelle; Plas, Aurelie; Kandepedu, Nishanth; Chalard, Pierre; Troin, Yves
Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 486 - 495
反应条件
hydrogen; palladium dihydroxide in methanol
参考文献
Journal of the American Chemical Society, , vol. 123, # 15 p. 3462 - 3471
反应条件
1.1: Et3N / tetrahydrofuran / 12 h / 50 °C 2.1: O3 / CH2Cl2 / -78 °C 2.2: dimethyl sulfide / CH2Cl2 / 12 h / -78 - 20 °C 3.1: NaClO2; aq. NaH2PO4 / 2-methyl-propan-2-ol; various solvent(s) / 20 °C 4.1: NaHCO3 / dimethylformamide / 12 h / 20 °C 5.1: H2 / Pd(OH)2/C / methanol View Scheme
参考文献
Journal of the American Chemical Society, , vol. 123, # 15 p. 3462 - 3471
反应条件
1: NH4OAc / methanol / 24 h / 50 °C 2: 57 percent / H2; (R,S)-tert-butyl Josiphos / [Ph(COD)Cl]2 / methanol / 18 h / 20 °C / 4654.33 - 5171.48 Torr View Scheme
参考文献
Organic Letters, , vol. 7, # 22 p. 4935 - 4938
反应条件
water in dimethylsulfoxide-d6 T=160°C; 12 h; Title compound not separated from byproducts.;
参考文献
Chemical Communications, , # 11 p. 1191 - 1193
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in toluene Barton-McCombie deoxygenation; Heating;
参考文献
Siddiqui, Shafi A.; Srinivasan, Kumar V.
Tetrahedron Asymmetry, 2007 , vol. 18, # 17 p. 2099 - 2103
