(3S)-3-[(叔丁氧羰基)氨基]-3-苯基丙酸甲酯合成路线 （共 32 条）
反应条件
1.1: 90 percent / thionyl chloride; triethylamine / CH2Cl2 / 0.75 h / 0 °C 2.1: 80 percent / sodium azide / dimethylformamide / 48 h / 80 °C 3.1: 88 percent / Et3N; hydrogen / Pd/C / ethyl acetate / 12 h / 20 °C / 760.05 Torr 4.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C 4.2: 82 percent / tetrahydrofuran; various solvent(s) / 2 h / 0 °C 5.1: 80 percent / tri-n-butyltin hydride; AIBN / toluene / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2099 - 2103
反应条件
1.1: 88 percent / Et3N; hydrogen / Pd/C / ethyl acetate / 12 h / 20 °C / 760.05 Torr 2.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C 2.2: 82 percent / tetrahydrofuran; various solvent(s) / 2 h / 0 °C 3.1: 80 percent / tri-n-butyltin hydride; AIBN / toluene / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2099 - 2103
反应条件
1.1: 83 percent / (DHQ)2PHAL; NMO; OsO4 / 2-methyl-propan-2-ol; H2O / 24 h / 20 °C 2.1: 90 percent / thionyl chloride; triethylamine / CH2Cl2 / 0.75 h / 0 °C 3.1: 80 percent / sodium azide / dimethylformamide / 48 h / 80 °C 4.1: 88 percent / Et3N; hydrogen / Pd/C / ethyl acetate / 12 h / 20 °C / 760.05 Torr 5.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C 5.2: 82 percent / tetrahydrofuran; various solvent(s) / 2 h / 0 °C 6.1: 80 percent / tri-n-butyltin hydride; AIBN / toluene / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2099 - 2103
反应条件
1.1: 80 percent / sodium azide / dimethylformamide / 48 h / 80 °C 2.1: 88 percent / Et3N; hydrogen / Pd/C / ethyl acetate / 12 h / 20 °C / 760.05 Torr 3.1: sodium hydride / tetrahydrofuran; various solvent(s) / 0.5 h / 0 °C 3.2: 82 percent / tetrahydrofuran; various solvent(s) / 2 h / 0 °C 4.1: 80 percent / tri-n-butyltin hydride; AIBN / toluene / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 17 p. 2099 - 2103
反应条件
C34H15F10NO4S2 in toluene T=20°C; Mannich Aminomethylation; Inert atmosphere; Reagent/catalystSolvent; enantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 135, # 41 p. 15334 - 15337
反应条件
C64H29F24NO4S2 in toluene T=20°C; Mannich Aminomethylation; Inert atmosphere; enantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 135, # 41 p. 15334 - 15337
反应条件
C64H29F24NO4S2 in toluene T=20°C; Mannich Aminomethylation; Inert atmosphere; enantioselective reaction;
参考文献
Journal of the American Chemical Society, , vol. 135, # 41 p. 15334 - 15337
反应条件
1: 4-DMAP / CH2Cl2 2: 1,3-dimethyl-2-phenyl-1,3,2-diazaphospholidine 3: 1.) 9-BBN, 2.) H2O2, NaOH / 1.) THF 4: PDC / dimethylformamide 5: diethyl ether View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 10 p. 1589 - 1592
反应条件
1: 1.) 9-BBN, 2.) H2O2, NaOH / 1.) THF 2: PDC / dimethylformamide 3: diethyl ether View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 10 p. 1589 - 1592
反应条件
1: PDC / dimethylformamide 2: diethyl ether View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 10 p. 1589 - 1592
