3-氨基-2,2二甲基乙酸合成路线 （共 19 条）
反应条件
1.1: ammonia / dichloromethane / 2.75 h / 20 °C / Cooling with ice 2.1: sodium hydroxide / methanol / 70 h / 50 - 53 °C / Sealed tube 2.2: 0.17 h / 0 - 20 °C View Scheme
参考文献
Journal of the Chemical Society, , p. 1502
Chem.Abstr., , p. 770
反应条件
barium dihydroxide; nickel Hydrogenation;
反应条件
1: iron; aqueous HCl 2: aqueous H2SO4 View Scheme
参考文献
Journal of the Chemical Society, , p. 1502
Chem.Abstr., , p. 770
反应条件
1: hydrogenchloride / 20 h / 20 °C 2: ammonia / methanol / 48 h / 60 °C / 3750.38 Torr / Autoclave View Scheme
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
反应条件
N-ethyl-N,N-diisopropylamine in N,N-dimethyl-formamide T=60°C; 16 h;
参考文献
ZALICUS PHARMACEUTICALS LTD .; PAJOUHESH , Hassan; ZHU, Yongbao; ZHOU, Yuanxi; GRIMWOOD, Mike; SIMONSON, Eric
Patent: WO2011/32291 A1, 2011 ;
Location in patent: Page/Page column 47 ;
WO 2011/032291 A1
反应条件
hydrogenchloride T=20°C; 20 h;
参考文献
Sandoz AG; ALBERT, Martin; DE SOUZA, Dominic; LANGNER, Martin
Patent: WO2012/10651 A2, 2012 ;
Location in patent: Page/Page column 19 ;
参考文献
Weyerstahl,P. et al.
Justus Liebigs Annalen der Chemie, 1969 , vol. 725, p. 106 - 115
反应条件
sodium hydrogencarbonate
参考文献
Kohn; Schmidt
Monatshefte fuer Chemie, 1907 , vol. 28, p. 1056
