5-[(氨基亚胺甲基)硫代]-L-正缬氨酸合成路线 （共 4 条）
反应条件
1: With boron trichloride in dichloromethane
T=20°C;
2: With methanol
参考文献
Han, Shoufa; Moore, Roger A.; Viola, Ronald E.
Bioorganic Chemistry, 2002 , vol. 30, # 2 p. 81 - 94
反应条件
1.1: TEA; ethyl chloroformate / tetrahydrofuran / 0.33 h / -5 °C
1.2: 80 percent / NaBH4 / H2O; tetrahydrofuran / 20 °C
2.1: 73 percent / TEA / CH2Cl2 / 3.5 h / 0 - 20 °C
3.1: 47 percent / acetone / Heating
4.1: BCl3 / CH2Cl2 / 20 °C
4.2: 82 percent / MeOH
View Scheme
参考文献
Han, Shoufa; Moore, Roger A.; Viola, Ronald E.
Bioorganic Chemistry, 2002 , vol. 30, # 2 p. 81 - 94
反应条件
1.1: 73 percent / TEA / CH2Cl2 / 3.5 h / 0 - 20 °C
2.1: 47 percent / acetone / Heating
3.1: BCl3 / CH2Cl2 / 20 °C
3.2: 82 percent / MeOH
View Scheme
参考文献
Han, Shoufa; Moore, Roger A.; Viola, Ronald E.
Bioorganic Chemistry, 2002 , vol. 30, # 2 p. 81 - 94
反应条件
1.1: 47 percent / acetone / Heating
2.1: BCl3 / CH2Cl2 / 20 °C
2.2: 82 percent / MeOH
View Scheme
参考文献
Han, Shoufa; Moore, Roger A.; Viola, Ronald E.
Bioorganic Chemistry, 2002 , vol. 30, # 2 p. 81 - 94
