(S)-γ-Valerolactone合成路线 （共 69 条）
反应条件
1.1: 47 percent Spectr. / Pseudomonas cepacia lipase / toluene / 24 h / 70 °C 2.1: LiOH / methanol / 12 h / 20 °C 2.2: HCl / methanol; H2O / 72 h / 70 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 70, # 7 p. 2582 - 2587
反应条件
1: 70 percent / pyridine / CHCl3 / 2.5 h / Ambient temperature 2: 1.) ZnCl2, NaBH4, 2.) 1M LiOH / 1.) THF, 2.) THF, room temperature View Scheme
参考文献
Tetrahedron, , vol. 53, # 44 p. 15061 - 15068
反应条件
1: 23 percent / sucrose / H2O / 48 h / 32 °C / baker's yeast 2: 1) O3, 2) Me2S / 1) MeOH, -78 deg C 3: p-toluenesulfonic acid / benzene / 0.33 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6197 - 6214
反应条件
1: 1) O3, 2) Me2S / 1) MeOH, -78 deg C 2: p-toluenesulfonic acid / benzene / 0.33 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6197 - 6214
反应条件
1: aq. AcOH / tetrahydrofuran 2: 1) O3, 2) Me2S / 1) MeOH, -78 deg C, 3h, 2) a) -78 deg C, 1 h, b) room temp., 3 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6197 - 6214
反应条件
1: toluene / Heating 2: aq. AcOH / tetrahydrofuran 3: 1) O3, 2) Me2S / 1) MeOH, -78 deg C, 3h, 2) a) -78 deg C, 1 h, b) room temp., 3 h View Scheme
参考文献
Tetrahedron, , vol. 47, # 32 p. 6197 - 6214
反应条件
toluene-4-sulfonic acid in benzene 0.333333 h; Heating; Yield given;
参考文献
Tetrahedron, , vol. 47, # 32 p. 6197 - 6214
反应条件
porcine pancreatic lipase in diethyl ether T=26°C; other γ-hydroxycarboxylic acid esters;
参考文献
Journal of Organic Chemistry, , vol. 55, # 11 p. 3546 - 3552
反应条件
1.1: 77 percent / MCPBA / CH2Cl2 / 17 h 2.1: ethanol / 20 °C 3.1: aq. KOH / 4 h / Heating 4.1: 0.94 g / dimethylformamide / 24 h / 20 °C 5.1: porcine pancreatic lipase / diethyl ether / 39 h / 30 °C 5.2: tributyltin hydride; 1,1'-azobis(cyclohexanecarbonitrile) / toluene / 2 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 34, # 5 p. 817 - 828
反应条件
1.1: ethanol / 20 °C 2.1: aq. KOH / 4 h / Heating 3.1: 0.94 g / dimethylformamide / 24 h / 20 °C 4.1: porcine pancreatic lipase / diethyl ether / 39 h / 30 °C 4.2: tributyltin hydride; 1,1'-azobis(cyclohexanecarbonitrile) / toluene / 2 h / Heating View Scheme
参考文献
Synthetic Communications, , vol. 34, # 5 p. 817 - 828
