二乙基2-(2-氯-6-氟苯基)丙二酸酯合成路线 （共 4 条）
反应条件
1: ethyl 2-(2-chloro-6-fluorophenyl)acetate With lithium hexamethyldisilazane in tetrahydrofuran T=-78°C; 0.5 h; 2: 1-ethoxycarbonyl-imidazole in tetrahydrofuran T=-78 - 20°C;
参考文献
Behera, Manoranjan; Venkat Ragavan; Sambaiah; Erugu, Balaiah; Rama Krishna Reddy; Mukkanti; Yennam, Satyanarayana
Tetrahedron Letters, 2012 , vol. 53, # 9 p. 1060 - 1062
反应条件
sodium hydride in tetrahydrofuran 8 h; Heating / reflux;
参考文献
Sumitomo Chemical Company, Limited
Patent: EP1431299 A1, 2004 ;
Location in patent: Page 12 ;
反应条件
hydrogenchloride; sodium ethanolate; magnesium in water
参考文献
American Cyanamid Company
Patent: US5750766 A1, 1998 ;
参考文献
American Cyanamid Company
Patent: US5750766 A1, 1998 ;
