(5-溴代戊)丙二酸二乙酯合成路线 （共 9 条）
反应条件
tetra-(n-butyl)ammonium iodide; potassium carbonate in water; toluene 20 h; Reflux;
参考文献
Monatshefte fur Chemie, , vol. 143, # 1 p. 153 - 159
反应条件
in diethyl ether; ethanol T=-2°C; 72 h;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 261 - 265
Zhurnal Organicheskoi Khimii, , vol. 19, # 2 p. 294 - 299
反应条件
ethanol; sodium ethanolate
参考文献
Bulletin de la Societe Chimique de France, , p. 1345,1350
Zhurnal Obshchei Khimii, , vol. 22, p. 1944,1951; engl. Ausg. S. 1993, 1998, 1999
反应条件
tetreamethyl ammonium hydroxide; lithium bromide in water; dimethyl sulfoxide T=25°C;
参考文献
Galli, Carlo; Mandolini, Luigi
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1984 , # 8 p. 1435 - 1438
参考文献
Gol'mow
Zhurnal Obshchei Khimii, 1952 , vol. 22, p. 1944,1951; engl. Ausg. S. 1993, 1998, 1999
反应条件
lithium aluminium tetrahydride; bromine; sodium carbonate 1.) 10 deg C, 1 h, ether; 2.) water; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Alagui, Abdelhakim; Apparu, Marcel; Comet, Michel; Pasqualini, Roberto; Vidal, Michel
Bulletin de la Societe Chimique de France, 1988 , # 1 p. 113 - 117
反应条件
1: 72 percent / dimethylsulfoxide / 3 h / 50 °C
2: 30percent aq.H2SO4 / aq. acetic acid / 16 h / Heating
3: 58 g / p-toluenesulfonic acid / benzene / 6 h / Heating
View Scheme
参考文献
Lapitskaya, M. A.; Manukina, T. A.; Nozdracheva, A. T.; Sheimina, L. G.; Pivnitskii, K. K.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 261 - 265
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 2 p. 294 - 299
反应条件
1: 72 percent / dimethylsulfoxide / 3 h / 50 °C
2: 30percent aq.H2SO4 / aq. acetic acid / 16 h / Heating
3: 58 g / p-toluenesulfonic acid / benzene / 6 h / Heating
View Scheme
参考文献
Lapitskaya, M. A.; Manukina, T. A.; Nozdracheva, A. T.; Sheimina, L. G.; Pivnitskii, K. K.
Journal of Organic Chemistry USSR (English Translation), 1983 , vol. 19, p. 261 - 265
Zhurnal Organicheskoi Khimii, 1983 , vol. 19, # 2 p. 294 - 299
反应条件
1: 76 percent / dimethylformamide / 1 h / 80 - 90 °C
2: 1.) aq. 5N NaOH, 2.) conc. HCl / 1.) dioxane, reflux, 2 h, 2.) 180 deg C, 12 min
View Scheme
参考文献
Takechi; Machida; Nishizono; Kanaoka
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 2 p. 188 - 196
