4-溴-1(2H)-酞嗪酮合成路线 （共 5 条）
反应条件
1: With phosphorus pentabromide in dichloromethane 24 h; Heating / reflux; 2: With acetic acid T=120°C; 2 h;
参考文献
Prime, Michael E.; Courtney, Stephen M.; Brookfield, Frederick A.; Marston, Richard W.; Walker, Victoria; Warne, Justin; Boyd, Andrew E.; Kairies, Norman A.; Von Der Saal, Wolfgang; Limberg, Anja; Georges, Guy; Engh, Richard A.; Goller, Bernhard; Rueger, Petra; Rueth, Matthias
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 312 - 319
反应条件
1: With acetic acid T=120°C; 2 h; 2: With water; acetic acid T=0 - 20°C;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2006/32518 A1, 2006 ;
Location in patent: Page/Page column 154; 155 ;
WO 2006/032518 A1
反应条件
in 1,2-dichloro-ethane 48 h; Heating / reflux;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2006/32518 A1, 2006 ;
Location in patent: Page/Page column 154 ;
WO 2006/032518 A1
反应条件
phosphorus pentabromide
参考文献
Prime, Michael E.; Courtney, Stephen M.; Brookfield, Frederick A.; Marston, Richard W.; Walker, Victoria; Warne, Justin; Boyd, Andrew E.; Kairies, Norman A.; Von Der Saal, Wolfgang; Limberg, Anja; Georges, Guy; Engh, Richard A.; Goller, Bernhard; Rueger, Petra; Rueth, Matthias
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 312 - 319
反应条件
1: ethanol / 80 °C 2: phosphorus pentabromide / 1,2-dichloro-ethane / 48 h / Reflux View Scheme
参考文献
Prime, Michael E.; Courtney, Stephen M.; Brookfield, Frederick A.; Marston, Richard W.; Walker, Victoria; Warne, Justin; Boyd, Andrew E.; Kairies, Norman A.; Von Der Saal, Wolfgang; Limberg, Anja; Georges, Guy; Engh, Richard A.; Goller, Bernhard; Rueger, Petra; Rueth, Matthias
Journal of Medicinal Chemistry, 2011 , vol. 54, # 1 p. 312 - 319
