氯[3-(二甲基氨基)丙基]镁合成路线 （共 34 条）
反应条件
1.1: tetrahydrofuran / 0.25 h / -5 °C 1.2: 0.5 h / -5 - 20 °C 1.3: pH 2 2.1: isopropyl alcohol / 3 h / 20 - 45 °C 3.1: ammonia / water / pH ~ 9 3.2: 3 h / -5 °C 4.1: isopropyl alcohol / 0.5 h / 50 - 60 °C View Scheme
参考文献
SHODHANA LABORATORIES LIMITED
Patent: US2011/92719 A1, 2011 ;
反应条件
1: toluene; tetrahydrofuran / 2.08 h / 5 - 18 °C 2: hydrogenchloride / toluene / 7 h / 90 °C View Scheme
参考文献
Sumitomo Chemical Company, Limited
Patent: EP2385045 A1, 2011 ;
反应条件
1: 5-bromo-3H-isobenzofuran-1-one; (4-fluoro-phenyl)-magnesium bromide in tetrahydrofuran; toluene
T=20°C; 1.5 h; Heating / reflux;
2: 3-(N,N-dimethylamino)-propylmagnesium chloride in tetrahydrofuran; toluene
T=20 - 30°C; 18 h;
3: With hydrogenchloride in tetrahydrofuran; water; toluene
T=20°C; 1 h;
参考文献
Pharmachem Technologies Limited
Patent: JP2005/507900 A, 2005 ;
Location in patent: Page/Page column 25 ;
参考文献
Engelhardt,E.L. et al.
Journal of Medicinal Chemistry, 1968 , vol. 11, # 2 p. 325 - 332
