6,7-二甲氧基-4-(4-氨基苯氧基)喹啉合成路线 （共 16 条）
反应条件
in tetrahydrofuran; N,N-dimethyl acetamide; water
参考文献
Exelixis, Inc.
Patent: US2012/252840 A1, 2012 ;
US 20120252840 A1
反应条件
1.1: 3.58 g / diphenyl ether / 1 h / 280 °C 2.1: aq. NaOH / methanol / 1 h / Heating 3.1: 2.3 g / diphenyl ether / 1 h / 280 °C 4.1: 85 percent / POCl3 / 0.5 h / Heating 5.1: NaH / dimethylsulfoxide / 0.17 h / 20 °C 5.2: 92 percent / dimethylsulfoxide / 3 h / 100 °C View Scheme
参考文献
Furuta, Takayuki; Sakai, Teruyuki; Senga, Terufumi; Osawa, Tatsushi; Kubo, Kazuo; Shimizu, Toshiyuki; Suzuki, Rika; Yoshino, Tetsuya; Endo, Megumi; Miwa, Atsushi
Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2186 - 2192
反应条件
1: 1,2-dichloro-benzene / -20 °C / |Reflux 2: trichlorophosphate / toluene / 1 h / 115 °C 3: N-ethyl-N,N-diisopropylamine / toluene / 24 h / 115 °C 4: potassium formiate; palladium 10 on activated carbon / water; tetrahydrofuran / 12 h / 73 °C View Scheme
参考文献
XI, Ning; WANG, Tingjin; ZENG, Shan; SUN, Mingming; WANG, Kunrui
Patent: WO2013/180949 A1, 2013 ;
反应条件
1: chlorobenzene / 120 °C View Scheme
参考文献
Shimizu, Toshiyuki; Fujiwara, Yasunari; Osawa, Tatsushi; Sakai, Teruyuki; Kubo, Kinya; Kubo, Kazuo; Nishitoba, Tsuyoshi; Kimura, Kaname; Senga, Terufumi; Murooka, Hideko; Iwai, Akemi; Fukushima, Kayoko; Yoshino, Tetsuya; Miwa, Atsushi
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 4 p. 875 - 879
反应条件
potassium carbonate in tetrahydrofuran; water T=15 - 30°C;
参考文献
WO2010/83414 A1, ;
Page/Page column 26 ;
反应条件
1: potassium carbonate / water; tetrahydrofuran / 0.33 h / 30 °C 2: water / butanone; water / 6 h / 20 - 74 °C View Scheme
参考文献
EXELIXIS, INC.; AFTAB, Dana, T.; CLARY, Douglas
Patent: WO2013/43840 A1, 2013 ;
