6-溴苯并[b]噻吩-2-甲酸合成路线 （共 12 条）
参考文献
WO2003/104227 A1, ;
Page 47, 48 ;
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=40°C; 2 h; 2: With hydrogenchloride in water pH=2;
参考文献
WO2009/39134 A1, ;
Page/Page column 159 ;
反应条件
potassium hydroxide in N,N-dimethyl-formamide T=20 - 140°C; 1.5 h;
参考文献
WO2007/92751 A2, ;
Page/Page column 36 ;
反应条件
sodium hydroxide; bromine T=0 - 20°C; 2.25 h;
参考文献
WO2007/140174 A2, ;
Page/Page column 26 ;
反应条件
1: triethylamine / acetonitrile / 85 °C / Inert atmosphere 2: water; lithium hydroxide hydrate / tetrahydrofuran / 2 h / 20 °C View Scheme
参考文献
WO2012/149413 A1, ;
WO 2012/149413 A1
反应条件
1: Natriumacetate / acetic acid / Heating 2: NaOH / H2O / Heating 3: 42 percent / CH3ONa / bis-(2-hydroxy-ethyl) ether / 1 h / 150 - 160 °C View Scheme
参考文献
Liebigs Annalen der Chemie, , # 3 p. 438 - 455
反应条件
1: NaOH / H2O / Heating 2: 42 percent / CH3ONa / bis-(2-hydroxy-ethyl) ether / 1 h / 150 - 160 °C View Scheme
参考文献
Liebigs Annalen der Chemie, , # 3 p. 438 - 455
反应条件
1: 97 percent / SOCl2 / pyridine / 3 h / Heating 2: 74 percent / ethanol / 2 h / Heating View Scheme
参考文献
Dann, Otto; Char, Helmut; Fleischmann, Paul; Fricke, Helmut
Liebigs Annalen der Chemie, 1986 , # 3 p. 438 - 455
反应条件
sulfuric acid T=65°C;
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/140174 A2, 2007 ;
Location in patent: Page/Page column 26-27 ;
反应条件
thionyl chloride in pyridine 3 h; Heating;
参考文献
Dann, Otto; Char, Helmut; Fleischmann, Paul; Fricke, Helmut
Liebigs Annalen der Chemie, 1986 , # 3 p. 438 - 455
