(E,Z)-1-溴-2-[4-[2-(二甲基氨基)乙氧基]苯基]-1,2-二苯基乙烯合成路线 （共 4 条）
反应条件
n-butyllithium 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, -78 deg C to RT, 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1491 - 1497
反应条件
2,2'-bis(di-p-tolyl-phosphino)-1,1'-binaphthyl; palladium diacetate; zinc(II) chloride in tetrahydrofuran; hexane T=25°C; Negishi coupling reaction; 18 h; optical yield given as percent de;
参考文献
Nunes, Carolina M.; Limberger, Jones; Poersch, Silvia; Seferin, Marcus; Monteiro, Adriano L.
Synthesis, 2009 , # 16 p. 2761 - 2765
反应条件
2,2'-bis(di-p-tolyl-phosphino)-1,1'-binaphthyl; palladium diacetate; zinc(II) chloride in tetrahydrofuran; hexane T=25°C; Negishi coupling reaction; 18 h; optical yield given as percent de;
参考文献
Nunes, Carolina M.; Limberger, Jones; Poersch, Silvia; Seferin, Marcus; Monteiro, Adriano L.
Synthesis, 2009 , # 16 p. 2761 - 2765
反应条件
n-butyllithium
1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, -78 deg C to RT, 30 min; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Foster; Jarman; Leung; McCague; Leclercq; Devleeschouwer
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1491 - 1497
