5-溴-1(2H)-异喹啉酮合成路线 （共 5 条）
反应条件
1: With 3-chloro-benzenecarboperoxoic acid in dichloromethane T=20°C; 0.5 h; 2: With acetic anhydride 1 h; Reflux;
参考文献
Kyowa Hakko Kirin Co., Ltd.; OTSUBO, Nobumasa; OKAZAKI, Shuko; TSUKUMO, Yukihito; IIDA, Kyoichiro; NAKOJI, Masayoshi
Patent: EP2708540 A1, 2014 ;
Location in patent: Paragraph 0122 ;
反应条件
ammonia in 2-methoxy-ethanol 8 h; Heating;
参考文献
Parveen, Ifat; Naughton, Declan P.; Whish, William J. D.; Threadgill, Michael D.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 2031 - 2036
反应条件
1: 99 percent / H2, aq. HCl / 10 percent Pd/C / tetrahydrofuran / 6 h 2: 35 percent / NaNO2, aq. H2SO4, KBr, CuBr / 2 h / 5 °C 3: 71 percent / NH3 / 2-methoxy-ethanol / 8 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 14 p. 2031 - 2036
反应条件
1: 35 percent / NaNO2, aq. H2SO4, KBr, CuBr / 2 h / 5 °C 2: 71 percent / NH3 / 2-methoxy-ethanol / 8 h / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 14 p. 2031 - 2036
反应条件
in diphenylether; dichloromethane 1 h; Heating; Yield given;
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 8 p. 1147 - 1156
