1-甲基-5-氧代脯氨酸甲酯合成路线 （共 17 条）
反应条件
potassium carbonate; triethylamine in acetone T=40°C; 6 h;
参考文献
Cauliez; Rigo; Fasseru; Couturier
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 1143 - 1146
反应条件
1: L-pyroglutamic acid methyl ester With sodium hydride in tetrahydrofuran T=0°C; 2: methyl iodide in tetrahydrofuran T=20°C; 1 h;
参考文献
US2008/9541 A1, ;
Page/Page column 15 ;
反应条件
potassium carbonate; triethylamine in ethylene glycol dimethyl ether; water T=20°C; 7 h;
参考文献
Cauliez; Rigo; Fasseru; Couturier
Journal of Heterocyclic Chemistry, 1991 , vol. 28, # 4 p. 1143 - 1146
反应条件
potassium carbonate in N,N-dimethyl-formamide
参考文献
US2013/190249 A1, ;
Page/Page column ;
反应条件
triethylamine in tetrahydrofuran T=80°C; 4 h;
参考文献
Fasseur, Dominique; Rigo, Benoit; Leduc, Catherine; Cauliez, Pascal; Couturier, Daniel
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 5 p. 1285 - 1291
反应条件
1: T=180 - 210°C; P=0.01 - 0.05 Torr; 2: With palladium 10 on activated carbon; hydrogen in methanol T=20°C; 24 h;
参考文献
Hasbullah, Siti Aishah; Jones, Simon
Tetrahedron Asymmetry, 2010 , vol. 21, # 21-22 p. 2719 - 2725
反应条件
2-nitro-benzyl bromide T=50°C; 8 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 33, # 4 p. 1063 - 1066
反应条件
1: 98 percent / paratoluenesulfonic acid / CHCl3 / 24 h / Heating 2: 82 percent / K2CO3 / Et3N / 1,2-dimethoxy-ethane; H2O / 7 h / 20 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 28, # 4 p. 1143 - 1146
参考文献
Lin, Nan-Horng
Tetrahedron Letters, 1995 , vol. 36, # 15 p. 2563 - 2566
反应条件
1: 12 h / 60 °C 2: 67 percent / Et3N / tetrahydrofuran / 4 h / 80 °C View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 29, # 5 p. 1285 - 1291
