(3S,4S)-N-Boc-3-氨基-4-羟基吡咯烷合成路线 （共 10 条）
反应条件
platinum(IV) oxide; hydrogen in methanol
参考文献
Martin-Rapun, Rafael; Fan, Xinyuan; Sayalero, Sonia; Bahramnejad, Mahboubeh; Cuevas, Felix; Pericas, Miquel A.
Chemistry - A European Journal, 2011 , vol. 17, # 32 p. 8780 - 8783
反应条件
1: With trifluoroacetic acid in methanol 2 h; 2: With hydrogen; platinum(IV) oxide in methanol 18 h;
参考文献
UCB PHARMA S.A.
Patent: WO2009/153554 A1, 2009 ;
Location in patent: Page/Page column 40 ;
WO 2009/153554 A1
反应条件
1.1: methanol / 15 h / 20 °C 2.1: m-CPBA / CH2Cl2 / 48 h / 20 °C 3.1: 1.29 kg / H2O / 5 h / 20 - 65 °C 4.1: (+)-mandelic acid / acetonitrile; H2O 4.2: 39 percent / 3 percent K2CO3 5.1: H2 / 5 percent Pd-C / ethanol / 5 h / 40 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 21 p. 2989 - 2997
反应条件
hydrogen; palladium on activated charcoal in ethanol T=40°C; 5 h;
参考文献
Tetrahedron Asymmetry, , vol. 12, # 21 p. 2989 - 2997
反应条件
hydrogen; platinum(IV) oxide in methanol 26 h; Ambient temperature; Yield given;
参考文献
Journal of Organic Chemistry, , vol. 62, # 12 p. 4197 - 4199
反应条件
1.1: 60 percent / NaH / dimethylformamide / 5.67 h / 20 - 50 °C 2.1: m-CPBA / CH2Cl2 / 48 h / 20 °C 3.1: 1.29 kg / H2O / 5 h / 20 - 65 °C 4.1: (+)-mandelic acid / acetonitrile; H2O 4.2: 39 percent / 3 percent K2CO3 5.1: H2 / 5 percent Pd-C / ethanol / 5 h / 40 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 21 p. 2989 - 2997
反应条件
1.1: m-CPBA / CH2Cl2 / 48 h / 20 °C 2.1: 1.29 kg / H2O / 5 h / 20 - 65 °C 3.1: (+)-mandelic acid / acetonitrile; H2O 3.2: 39 percent / 3 percent K2CO3 4.1: H2 / 5 percent Pd-C / ethanol / 5 h / 40 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 21 p. 2989 - 2997
反应条件
1.1: 1.29 kg / H2O / 5 h / 20 - 65 °C 2.1: (+)-mandelic acid / acetonitrile; H2O 2.2: 39 percent / 3 percent K2CO3 3.1: H2 / 5 percent Pd-C / ethanol / 5 h / 40 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 12, # 21 p. 2989 - 2997
反应条件
1: sodium carbonate 2: platinum(IV) oxide; hydrogen / methanol View Scheme
参考文献
Chemistry - A European Journal, , vol. 17, # 32 p. 8780 - 8783
反应条件
1: sodium azide / N,N-dimethyl-formamide / 100 °C 2: trifluoroacetic acid / dichloromethane / 0.5 h 3: 10 palladium on activated charcoal; hydrogen / methanol View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 4 p. 1612 - 1621
