1: 68 percent / TiCl4 / benzene / 4 h / Heating 2: 85 percent / pyridine, 4-DMAP / 8 h / 50 °C 3: t-BuOK / 2-methyl-propan-2-ol / 2 h / 60 °C 4: 1.) NaH / 1.) HMPA, RT, 2.) HMPA, RT, 20 min View Scheme

<b>Multi-step reaction with 7 steps<br /> </b>1: 54 percent / DEAD, n-Bu₃P / tetrahydrofuran / 42 h / Ambient temperature<br />2: 1.) n-BuLi, 2.) CuCN-TMEDA, 3.) O₂ <br />3: 90 percent / H₂ / 10percent Pd/C / ethyl acetate / 12 h<br />4: 92 percent / pyridine / 8 h / 0 &deg;C<br />5: 96 percent / NaI / acetone / 3 h / Heating<br />6: Zn, EtOH / 1 h / Heating<br />7: 93 percent / pyridine / 2 &deg;C<br /> <br /> &nbsp;