(S)-3-(叔丁氧羰基氨基)-2-甲基丙酸合成路线 (共 2 条)
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 15 h; 2: With hydrogenchloride in water; ethyl acetate
参考文献
LG LIFE SCIENCES, LTD.
Patent: WO2008/93960 A1, 2008 ;
Location in patent: Page/Page column 25-26 ;
WO 2008/093960 A1
反应条件
sodium chlorite; sodium dihydrogen phosphate monohydrate; 2-methyl-but-2-ene in water; tert-butyl alcohol 5 h; optical yield given as percent ee;
参考文献
Zhang, Xiaowei; Cao, Bonan; Yu, Shichao; Zhang, Xumu
Angewandte Chemie - International Edition, 2010 , vol. 49, # 24 p. 4047 - 4050