1-Boc-1,4-二氮杂-5-环庚酮合成路线 （共 8 条）
反应条件
1-propanephosphonic acid cyclic anhydride in tetrahydrofuran; ethyl acetate T=70°C; Beckmann rearrangement; Inert atmosphere;
参考文献
Augustine, John Kallikat; Kumar, Rajesha; Bombrun, Agnes; Mandal, Ashis Baran
Tetrahedron Letters, 2011 , vol. 52, # 10 p. 1074 - 1077
反应条件
in tetrahydrofuran T=10 - 20°C; 2 h;
参考文献
LEO PHARMA A/S; NIELSEN, Simon, Feldbaek; GREVE, Daniel, Rodriguez; GRUE-SOERENSEN, Gunnar; RYTTERSGAARD, Carsten; SCHOU, Soeren, Christian; SAMS, Anette, Graven
Patent: WO2012/3829 A1, 2012 ;
Location in patent: Page/Page column 59 ;
WO 2012/003829 A1
反应条件
1: With triethylamine in acetonitrile T=20°C; 0.5 h; 2: in water; acetonitrile T=20°C;
参考文献
EP1477490 A1, ;
Page 109 ;
EP 1477490 A1
反应条件
sodium hydroxide; sodium chloride; Pearlman's catalyst in chloroform; water 4 h; Heating / reflux;
参考文献
Merck and Co., Inc.
Patent: US6372733 B1, 2002 ;
Location in patent: Example 1 ;
反应条件
in tetrahydrofuran T=20°C; 15 h;
参考文献
US2006/25383 A1, ;
Page/Page column 71-72 ;
US 20060025383 A1
反应条件
1: H2 / Pd(OH)2 / ethanol / 20 °C 2: CH2Cl2 / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 23 p. 5907 - 5911
反应条件
1: hydroxylamine hydrochloride; sodium acetate / methanol; water / Reflux 2: 1-propanephosphonic acid cyclic anhydride / tetrahydrofuran; ethyl acetate / 70 °C / Inert atmosphere View Scheme
参考文献
Tetrahedron Letters, , vol. 52, # 10 p. 1074 - 1077
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin; Spear, Kerry L.
Patent: US2010/204214 A1, 2010 ;
Location in patent: Page/Page column 108-109 ;
