3,4-二氢-2-甲基-4-氧代吡啶-1(2H)-甲酸苄酯合成路线 （共 15 条）
反应条件
1: in tetrahydrofuran T=-25°C; 4 h; 2: With hydrogenchloride in tetrahydrofuran T=20°C; 0.166667 h; Further stages.;
参考文献
Kitagawa, Hideo; Ozawa, Tomohiro; Takahata, Sho; Iida, Maiko; Saito, Jun; Yamada, Mototsugu
Journal of Medicinal Chemistry, 2007 , vol. 50, # 19 p. 4710 - 4720
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
US5756508 A1, ;
US 5756508 A
反应条件
acetic acid; zinc T=80°C; 12 h;
参考文献
Richards, Steven; Sorensen, Bryan; Jae, Hwan-soo; Winn, Marty; Chen, Yixian; Wang, Jiahong; Fung, Steven; Monzon, Katina; Frevert, Ernst U.; Jacobson, Peer; Sham, Hing; Link
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6241 - 6245
反应条件
1: 80 percent / Zn; AcOH / 12 h / 80 °C 2: H2 / Pd/C / methanol / 12 h / 760 Torr View Scheme
参考文献
Richards, Steven; Sorensen, Bryan; Jae, Hwan-soo; Winn, Marty; Chen, Yixian; Wang, Jiahong; Fung, Steven; Monzon, Katina; Frevert, Ernst U.; Jacobson, Peer; Sham, Hing; Link
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6241 - 6245
反应条件
palladium on activated charcoal; hydrogen in ethanol
参考文献
Jones, T. Nicholas; McClure, Cynthia K.
Synlett, 2009 , # 8 p. 1289 - 1290
反应条件
1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
2: pyridine / 20 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C
4: 93 percent / hydrogen / Pd/C / methanol / 0.17 h / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Atsumi, Kunio
Chemistry Letters, 2006 , vol. 35, # 7 p. 712 - 713
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 1 h / -78 °C
2.1: pyridine / 20 °C
3.1: potassium tert-butoxide / tetrahydrofuran / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Atsumi, Kunio
Chemistry Letters, 2006 , vol. 35, # 7 p. 712 - 713
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 1 h / -78 °C
2.1: pyridine / 20 °C
3.1: potassium tert-butoxide / tetrahydrofuran / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Atsumi, Kunio
Chemistry Letters, 2006 , vol. 35, # 7 p. 712 - 713
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 1 h / -78 °C
2.1: pyridine / 20 °C
3.1: potassium tert-butoxide / tetrahydrofuran / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Atsumi, Kunio
Chemistry Letters, 2006 , vol. 35, # 7 p. 712 - 713
反应条件
1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
2: pyridine / 20 °C
3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20 °C
4: hydrogen / Pd/C / methanol / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Atsumi, Kunio
Chemistry Letters, 2006 , vol. 35, # 7 p. 712 - 713
