3,4-二氢-2-甲基-4-氧代吡啶-1(2H)-甲酸苄酯合成路线 （共 15 条）
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: 98 percent / tetrahydrofuran / 1 h / -78 °C
2.1: 94 percent / pyridine / 3 h / 20 °C
3.1: 87 percent / potassium tert-butoxide / tetrahydrofuran / 0.17 h / 20 °C
4.1: 72 percent / sodium hydride / dimethylformamide / 6 h / 50 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Takahata, Sho; Iida, Maiko; Atsumi, Kunio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1106 - 1116
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 1 h / -78 °C
2.1: pyridine / 20 °C
3.1: potassium tert-butoxide / tetrahydrofuran / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Takahata, Sho; Iida, Maiko; Atsumi, Kunio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1106 - 1116
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 1 h / -78 °C
2.1: pyridine / 20 °C
3.1: potassium tert-butoxide / tetrahydrofuran / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Takahata, Sho; Iida, Maiko; Atsumi, Kunio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1106 - 1116
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 1 h / -78 °C
2.1: pyridine / 20 °C
3.1: potassium tert-butoxide / tetrahydrofuran / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Takahata, Sho; Iida, Maiko; Atsumi, Kunio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1106 - 1116
反应条件
1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C
1.2: tetrahydrofuran / 1 h / -78 °C
2.1: pyridine / 20 °C
3.1: potassium tert-butoxide / tetrahydrofuran / 20 °C
View Scheme
参考文献
Kitagawa, Hideo; Kumura, Ko; Takahata, Sho; Iida, Maiko; Atsumi, Kunio
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1106 - 1116
